ANA Testing: What You Need to Know



ANA (antinuclear antibodies) occur in patients with a variety of autoimmune diseases, both systemic and organ-specific. They are particularly common in systemic rheumatic diseases, which include lupus erythematosus (LE), discoid LE, drug-induced LE, mixed connective tissue disease, Sjogren syndrome, scleroderma (systemic sclerosis), CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) syndrome, polymyositis /dermatomyositis, and rheumatoid arthritis. 

 

Autoimmune diseases that can cause a positive ANA result include:

  • Systemic lupus erythematosus (SLE): SLE (lupus) is an inflammatory disease. It causes joint pain, fever, weakness, fatigue, skin rashes and organ damage.
  • Scleroderma: Scleroderma is a rare disease that causes abnormal thickening and hardening of your child’s skin and tissues. It can also affect your child’s gastrointestinal tract, lungs, kidneys, heart, blood vessels, muscles and joints.
  • Polymyositis: Polymyositis is a disease of your child’s muscles that causes inflammation and weakness. It usually affects the muscles closest to your child’s trunk.
  • Dermatomyositis: Dermatomyositis occurs when people have disease features of polymyositis and also skin involvement such as a scaly rash, swelling, and purple spots.
  • Mixed connective tissue disease (MCTD): MCTD shares features with SLE, scleroderma and polymyositis. Usually, the symptoms of these diseases don’t occur at the same time. Rather, they occur one after the other over a long period of time.
  • Juvenile onset idiopathic arthritis (JIA): JIA is a type of arthritis that may affect the joints in a variety of ways in your child’s body. Their hands, wrists, knees, and other joints may be affected. It may also affect other parts of your child’s body, including their skin, eyes, lungs, heart and blood.
  • Sjögren’s syndrome: Sjögren’s syndrome is a condition that reduces the amount of moisture produced by the glands in your child’s eyes and mouth. Your child’s immune system damages the tear system in their eyes and the salivary glands in their mouth.

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